STem Cells and regenerative treatments role in inflammatory conditions and long Covid

Cancer, aging, and severe COVID-19 have all been linked to damage from inflammation

Inflammation evolved to serve an important function: It rids our bodies of stuff that doesn’t belong, including foreign invaders like bacteria and viruses, tumor cells, and irritants like splinters.

When inflammation becomes chronic, though, the chemical weapons deployed by front-line immune cells often damage healthy tissue, and our bodies become collateral damage. The price exacted includes worn joints, neuron loss,  damaged kidneys, and more. Autoimmune diseases like rheumatoid arthritis and lupus, characterized by pain and worsening disability, have long been associated with persistent inflammation.

In extreme cases, such as the cytokine storms associated with sepsis or severe COVID-19, inflammation can destroy and disable multiple organs, leading to multıple organ failure.

Simply stopping inflammation is not enough to return tissue to its normal state. This approach ignores the other side of the inflammation coin: resolution.

Resolving inflammation is an active, highly choreographed process for rebuilding tissue and removing the dead bacteria and cells. When that process is disrupted, inflammatory diseases arise.

Within minutes of their introduction into the bloodstream ,our stem cell transfusions  start to release tiny molecules (microRNAs) which signal every organ in the body to rejuvenate and repair. The brain starts to release neural stem cells which are the stem cells that can repair the brain, the heart releases cardiac stem cells, the lung pulmonary stem cells and the skin mesenchymal stem cells. Leaving the skin looking more healthier than before and as the stem lines we use,are by far the most effective form of stem cells for reversing the effects of aging.

stem cells research into the role of INFLAMMATION

In the early 2000s researchers began to recognize the role of inflammation in conditions as varied as Alzheimer’scancerdiabetes, and heart disease, prompting them to recast inflammation as the unifying explanation for a myriad of ailments, including those we develop as we age. Even aging itself, and its associated pathologies, is driven by persistent inflammation.

Like inflammations’ onset, its resolution is orchestrated by an army of signaling molecules. 

Stem cells’ ability to protect damaged tissue and differentiate into a range of cells by secreting trophic, immune-modulatory, or other therapeutic factors   which dictate orders to an army of signaling molecules. 

Making this form of treatment  an excellent choice in anti inflammatory  therapy.

Scientists speculate that one way stem cells and other pro-resolution molecules work is by interacting with immune cells called macrophages.

Initially, when the danger posed by invaders is at its peak, the macrophages drawn to the area are inflammatory—secreting pro-inflammatory cytokines and amping up production of antimicrobial agents. But this balance shifts as the tide of the confrontation turns. After the number of viruses declines, the debris left behind—viral remnants, dead immune cells, and other waste—must be collected and cleared away before it sparks another cycle of inflammation. That’s when the macrophages switch gears.

Attracted by “eat me” signals expressed on the surface of dying cells, macrophages readily engulf and clear cellular corpses from the environment. 

But it’s not just about clearing the wreckage—this act also flips a genetic switch, reprogramming macrophages to restore balance to the system and heal the tissues.

“Macrophages under the instruction from the body and stem cells start to produce factors that tell the local tissue, Don’t recruit any more inflammatory cells here, or, Let’s proliferate and start repairs there,”

Clearing away cellular debris

Now consensus is building that many of the illnesses attributed to inflammation—both chronic and acute—can be traced to a failure in resolution. Often that translates into a failure to clear away dead cells.

Our EBOO therapy clears the vast majorıty of unwanted cellular debrıs and other ınflammatory reactive cell molecules and viral bacterial fragments left floating in your blood cırculation.

If you knock out receptors in the macrophages of mice that recognize dying cells, for example, they become incapable of eating up these cells, resulting in a lupus-like disease,” with symptoms such as arthritis and skin rash.

A similar mechanism is at work in older people. As we age, the body loses a protein that recognizes dying cells; this blocks macrophages’ ability to find and eat debris. Locked in a pro-inflammatory state, these macrophages continue to produce molecules that amplify the inflammatory response early on.

It has been postulated  that COVID-19 has been more severe in older populations because of the  loss of some of the pro-resolution pathways with age, COVID-19 has also been problematic for people with genetic differences that impact immune function, resulting in overactive inflammatory responses or underactive pro-resolving ones. 

Cancer is affected when inflammation fails to resolve. The soup of toxins, growth factors, and other inflammatory by-products that accompany inflammation spurs cancer’s growth and spread. 

Chemotherapy and radiation are like sledgehammers. They may kill the tumor, but the debris they create stimulates inflammation, which feeds circulating tumor cells that survive the treatment.”

Long covid and inflammation

The uncontrolled inflammatory response seen ın Covid, is referred to as a cytokines storm. This cytokine release is characterized by an increase in IL-1, IL-6, TNF-α and a change in macrophages population. Thus, COVID-19 can cause neuroinflammation that might be prolonged and lead to signs of post-COVID-19 syndrome.

The Micro-infarcts and neuroinflammation are important causes of local hypoxia, and specifically neurological hypoxia. One of the options to reverse hypoxia, reduce neuroinflammation and induce neuroplasticity is hyperbaric oxygen therapy (HBOT).

Hyperbaric oxygen therapy (HBOT) includes the inhalation of 100% oxygen at pressures exceeding 1 atmosphere absolute, thus enhancing the amount of oxygen dissolved in the body tissues. During HBOT, the arterial O2 tension typically exceeds 2000 mmHg, and levels of 200-400 mmHg occur in tissues Even though many of the beneficial effects of HBOT can be explained by improvement of tissue oxygenation, it is now understood that the combined action of hyperoxia and hyperbaric pressure, triggers both oxygen and pressure sensitive genes, resulting in inducing regenerative processes including stem cells proliferation and mobilization with anti-apoptotic and anti-inflammatory factors.

Hyperbaric oxygen therapy is currently being used and studied as an effective form of treatment for lingering COVID-19 symptoms due to its ability to reverse hypoxia, reduce neuro-inflammation, and improve tissue oxygenation amongst other benefits.

Healing for Life Clinic
Poseidonia Healthcare’s treatment philosophy is to provide a multi-treatment approach to return your health and wellbeing to you in the fastest possible way. We supply the most comprehensive combination of treatments all in one location. Combining Ozone Therapy, Hyperbaric Oxygen Therapy, Cryotherapy the most advanced Stem Cell Treatments available in the world and a comprehensive Detoxification program all under one roof!

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